Analog Selection in Pharma Forecasting: Getting It Right and Getting It Wrong
Every pharma forecast eventually leans on a comparison. Somewhere in the model there is a line that says, in effect, “our product will behave roughly like that one.” That product is the analog, and th ...
Which TPP Attributes Actually Matter? A Sensitivity-Driven Approach to Optimization
A Target Product Profile usually arrives as a table: indication, line of therapy, efficacy target, safety expectations, dosing, route of administration, positioning. Every row looks equally reasonable ...
The Evolution of PD-1/PD-L1: From Immune Checkpoint Breakthrough to What Comes After Keytruda
The protein was named for the wrong job. In 1992, Tasuku Honjo's group at Kyoto University was hunting for genes tied to cell death in T cells and cloned a new one. They called it programmed death-1, ...
Gorlin Syndrome Treatment Burden Problem: What the Patidegib Readout Could Change
Patients with severe Gorlin syndrome can face repeated surgeries year after year, many of them on the face. Each one can leave a scar, and a face only has so much tissue to spare.Most people meet basa ...
Forecasting Rare Disease Markets: Why Small Patient Populations Demand a More Rigorous Model
Rare disease markets have an odd commercial paradox built into them: the patient population is tiny, but the market opportunity can still be substantial. That's what makes forecasting them fundamental ...
What’s Driving R&D in Triple-Negative Breast Cancer
For years, chemotherapy was the backbone of triple-negative breast cancer (TNBC) treatment because the disease lacked the molecular targets that transformed treatment in other breast cancer subtypes. ...
Beyond the Static Document: Why Evidence-Driven TPP Optimization Is Becoming a Strategic Imperative in Pharma
Every drug development program starts with a hypothesis about the product it hopes to become. The Target Product Profile (TPP) is where that hypothesis is written down: the intended indication, the ef ...
Primary Market Research in Pharma: Turning Stakeholder Perspectives into Actionable Decisions
In pharma, more data doesn't always mean better answers.Secondary research can tell a team what has happened in a market, such as prescription trends, treatment shares, clinical developments, competit ...
The Evolution of HEOR in Rare Diseases: From Cost-Effectiveness to Strategic Market Access
There used to be a simple rule in pharma: scientists built the drug, clinical teams proved it worked, and health economists showed up near the end to do the math. Run the trial, demonstrate efficacy, ...
HER2-Positive Metastatic Breast Cancer: The Treatment Shift Reshaping the Market
A Decade of Reinvention There was a time when a HER2-positive breast cancer diagnosis carried a particularly difficult outlook. The biology was aggressive, treatment options were limited, and metasta ...