Pulmonary Arterial Hypertension (PAH) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Pulmonary Arterial Hypertension (PAH) Market Outlook

Thelansis’s “Pulmonary Arterial Hypertension (PAH) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Pulmonary Arterial Hypertension treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Pulmonary Arterial Hypertension (PAH) Overview

Pulmonary arterial hypertension (PAH) is a progressive and chronic condition marked by antiproliferative changes in the pulmonary arterioles, resulting in endothelial and smooth muscle proliferation and dysfunction, inflammation, and the formation of blood clots. PAH is primarily caused by remodeling pulmonary arteries, narrowing and obstructing the smallest arteries. This increased resistance in the pulmonary circulation results in elevated pressure within the right ventricle. Specific gene mutations, including BMPR2 (2q33), ACVRL1 (12q13), Endoglin (9q34), CAV1 (7q31), KCNK3 (2p23), Smad9 (13q12), and TBX4 (17q21), have been associated with heritable PAH. Most cases of PAH typically develop in adults, with occasional occurrences in children. Women are twice as likely as men to be affected by this condition. Initial symptoms include shortness of breath, fainting, chest discomfort, palpitations, and swelling in the lower extremities. Clinical signs include a prominent and palpable second heart sound, a pulmonary ejection click, and murmurs related to pulmonary and tricuspid regurgitation—approximately 70% of patients present with severe heart failure. Less frequently, symptoms such as abdominal swelling, clubbing of the fingers, and Raynaud's phenomenon (predominantly in females) may also manifest. Hemoptysis has been reported but is relatively rare. Treatment strategies encompass general measures, such as aggressive management of respiratory tract infections, annual influenza vaccinations, family planning, and medical therapies like oxygen supplementation, anticoagulation, diuretics, and digoxin. Calcium channel blockers are appropriate for patients with acute vasodilator response to nitric oxide during right heart catheterization. Additional therapeutic options include endothelin receptor agonists like ambrisentan, prostanoids like epoprostenol, and phosphodiesterase inhibitors like sildenafil. Lung transplantation remains the last resort for patients who do not respond to other treatment modalities. The prognosis varies depending on the specific form of PAH, but it is generally grim, with a mean survival rate of less than three years following diagnosis. However, early intervention with appropriate therapies can improve survival rates.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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