Retinoblastoma – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Retinoblastoma Market Outlook

Thelansis’s “Retinoblastoma Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Retinoblastoma treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Retinoblastoma Overview

Retinoblastoma, although rare, stands as the predominant ocular neoplasm in childhood. It emerges as a malignant proliferation originating from the developing retina, typically manifesting before age five. This tumor arises from cells harboring cancer-predisposing variants in both alleles of the RB1 gene. Its presentation may be unifocal or multifocal. Approximately 60% of cases present as unilateral retinoblastoma, with a mean diagnosis age of 24 months, while around 40% present with bilateral involvement, typically diagnosed at 15 months of age. Heritable retinoblastoma follows an autosomal dominant pattern, increasing susceptibility to the disease and predisposing affected individuals to non-ocular tumors. The prognosis of localized disease is favorable for long-term survival, in stark contrast to metastatic retinoblastoma, characterized by aggressive behavior and dismal outcomes. The genetic underpinning of retinoblastoma is well-established, with evidence suggesting autosomal dominant inheritance, particularly notable in bilateral cases. Retinoblastoma treatment strategies are comprehensive and aim at life-saving and vision-preserving measures. Intraocular disease exhibits high responsiveness to treatment, with over 90% of patients achieving survival. Chemotherapeutic regimens, such as the combination of carboplatin, etoposide phosphate, and vincristine sulfate, capitalize on synergistic effects to enhance efficacy, exploiting distinct mechanisms of action against cancer cells.

• In the United States, retinoblastoma afflicts approximately 11.8 cases per million live births among children under 5 years old, representing around 2% of all childhood malignancies. The disease predominantly affects infants and toddlers, with an average onset at 2 years of age, while occurrences beyond the age of six are exceedingly rare.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

Visit our social media pages: