Malignant Peripheral Nerve Sheath Tumors (MPNSTs) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) Market Outlook

Thelansis’s “Malignant Peripheral Nerve Sheath Tumors (MPNSTs) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Malignant Peripheral Nerve Sheath Tumors treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Malignant Peripheral Nerve Sheath Tumors Overview

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive soft tissue tumors that primarily originate from the peripheral nerves. They demonstrate variable differentiation towards the cellular components of the nerve sheath, such as Schwann cells, fibroblasts, or perineurial cells. MPNSTs are common in adults with no gender bias but tend to occur at a younger mean age in patients with neurofibromatosis type 1 (NF1). The tumors are most frequently found in the extremities, particularly proximally, followed by the trunk, head, and neck. The sciatic nerve is the most commonly involved major nerve trunk. Clinical presentation includes a painful or rapidly growing mass and associated neurologic deficits. Approximately half of the MPNSTs arise in the context of NF1 syndrome, often associated with pre-existing plexiform neurofibromas. The lifetime risk of developing MPNST in NF1 patients is 8-13%. An important symptom is developing new, worsening, or persistent pain in a neurofibroma in an NF1 patient. Patients present with a rapidly growing mass that may be painful or cause local neurological symptoms such as weakness or paresthesia. At presentation, the mass is commonly larger than 5 cm, and up to 50% of patients present with metastatic disease, usually to the lung. In cases of localized disease, surgical extirpation with clear margins is the treatment of choice.

• The estimated incidence of malignant Peripheral Nerve Sheath Tumors in the USA is 1.46 per 1,000,000.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2022-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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