Glioblastoma (GBM) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Glioblastoma (GBM) Market Outlook

Thelansis’s “Glioblastoma (GBM) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Glioblastoma treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Glioblastoma (GBM) Overview

Glioblastoma (GBM) is the most aggressive among the diffuse gliomas originating from the astrocytic lineage. It ranks as the most prevalent malignant primary brain tumor, comprising 54% of all gliomas and 16% of primary brain tumors. GBM is classified as a malignant astrocytic tumors, earning a Grade IV designation according to the WHO classification. The exact cause of this disease remains unknown, except in cases where it emerges following therapeutic brain irradiation for other conditions. The genetic anomalies identified, such as EGFR gene amplification (7p12), TP53 gene mutations (17p13.1), and chromosome 10 loss, vary depending on the tumor's nature: primary glioblastoma (de novo) or secondary glioblastoma (arising from a benign astrocytic tumor). Glioblastomas can develop at any age. They are most commonly observed in patients between 45 and 70, making up 70% of cases in this age group. Typically, these tumors are situated in the brain hemispheres but can occur throughout the central nervous system. The disease often exhibits rapid progression, usually 2 to 3 months, except in cases where it evolves from a pre-existing low-grade astrocytoma (secondary glioblastoma). Primary treatment typically involves surgery to confirm the diagnosis via biopsy or maximize tumor removal. Complete resection is rarely achievable due to the tumor's tendency to infiltrate the surrounding brain tissue. Following surgery, treatment continues with targeted radiotherapy focused on the tumor site, often supplemented with chemotherapy involving nitrosoureas and temozolomide. Adjuvant therapies post-surgery yield significant benefits in terms of survival, albeit with modest outcomes. In cases of relapse, second-line chemotherapy or repeat surgery may be considered. Given the tumor's relative rarity, managing glioblastoma patients necessitates a multidisciplinary approach from neuro-oncology experts within prospective studies to enhance patient survival and quality of life. In the absence of gross total resection in elderly patients and cases of severe neurological deficits, the prognosis is poor.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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