Eosinophilic Esophagitis (EoE) Emerging Therapy and TPP Insights

Thelansis’s “Eosinophilic Esophagitis (EoE) Emerging Therapy, with Unmet Needs and TPP Insights Report – 2025″ provides a comprehensive analysis of the emerging competitive landscape, unmet needs, target product profiles (TPPs), trial designs, and KOL insights on key emerging therapies and key drug development opportunities in the indication.

Eosinophilic Esophagitis (EoE) Overview

Eosinophilic Esophagitis (EoE), often described as the “asthma of the esophagus,” is a chronic, immune‑driven allergic condition marked by dense eosinophil infiltration of the esophageal lining, which causes ongoing inflammation and progressive impairment of esophageal structure and function. The clinical presentation varies with age: in adults, the most common symptoms include dysphagia, food impaction, chest discomfort, and heartburn, whereas in children it more frequently manifests as vomiting, abdominal pain, regurgitation, and feeding difficulties, with swallowing problems and food blockages becoming increasingly evident during adolescence. Diagnosis requires endoscopic biopsy demonstrating ≥15 eosinophils per high‑power field in the esophagus, with exclusion of eosinophilic involvement in the stomach or duodenum. The condition is strongly associated with atopy, as up to three‑quarters of patients have a personal or family history of asthma, eczema, allergic rhinitis, or food/environmental allergies. Unlike gastroesophageal reflux disease, EoE typically does not respond to acid‑suppression therapy, and management relies on dietary elimination of allergens, swallowed topical corticosteroids, and endoscopic dilation for strictures, with long‑term monitoring needed to prevent complications.

Geography coverage:

G8 (United States, EU5 [France, Germany, Italy, Spain, U.K.], Japan, and China)

Insights driven by surveys* with physician / key opinion leaders:

• Survey findings are corroborated and enriched by insights from interviews with leading KOLs

*Survey is customized based on client requirements

Deliverables format:

• PowerPoint presentation
• MS Excel

Key business questions answered:

• Detailed emerging competitive landscape
  • Pipeline analysis
  • Target patients for emerging therapies
  • Key companies
  • Key mechanism of actions
  • Launch date estimates, etc.
• Clinical trial landscape analysis
  • Target patient segments
  • Trial endpoints
  • Trial design
  • Recruitment criteria, etc.
• Unmet Needs and Opportunities
  • Performance of key current therapies
  • Top areas of unmet needs
  • Opportunity sizing for key unmet needs
• Target Product Profiles
  • Attributes and levels
  • Physician likelihood of prescribing
  • Expected patient shares
• KOL insights on key emerging therapies
  • Level of awareness
  • Expected use / line of therapy
  • Extent to fulfil key unmet needs
  • KOL quotes

1. Key Findings and Analyst Commentary

• Key trends: market snapshots, SWOT analysis, commercial benefits and risk,etc.

2. Disease Context

• Disease definition, classification, etiology and pathophysiology, drug targets,etc.

3. Epidemiology

• Key takeaways
• Incidence / Prevalence
• Diagnosed and Drug-Treated populations
• Comorbidities
• Other relevant patient segments

4. Market Size and Forecast

• Key takeaways
• Market drivers and constraints
• Drug-class specific trends
• Country-specific trends

5. Competitive Landscape

• Current therapies
  • Key takeaways
  • Dx and Tx journey/algorithm
  • Key current therapies – profiles and KOL insights
• Emerging therapies
  • Key takeaways
  • Notable late-phase emerging therapies – profiles, launch expectations, KOL insights
  • Notable early-phase pipeline

6. Unmet Need and TPP Analysis

• Top unmet needs and future attainment by emerging therapies
• TPP analysis and KOL expectations

7. Regulatory and Reimbursement Environments (by country and payer insights)

8. Appendix (e.g., bibliography, methodology)