Clostridioides Difficile Infection (CDI) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032

Clostridioides Difficile Infection (CDI) Market Outlook

Thelansis’s “Clostridioides Difficile Infection (CDI) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Clostridioides Difficile Infection (CDI) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Clostridioides Difficile Infection (CDI) Overview

Clostridioides difficile infection (CDI) is caused by an anaerobic, spore-forming, gram-positive bacterium that resides in the intestinal tract of individuals, particularly those whose normal gut microbiota has been disrupted due to antibiotic therapy or other factors. C. difficile bacterium produces two primary toxins, A and B, which damage the intestinal mucosa, leading to symptoms such as diarrhea and colitis. In severe cases, the infection can progress to shock, ileus, and toxic megacolon. In high-income countries, C. difficile infection is the leading cause of infectious diarrhea among hospitalized patients. Initial antibiotic treatment fails in 20% to 35% of cases; 40% to 60% experience a second recurrence among these individuals. The recurrence of C. difficile infection after the initial treatment imposes significant morbidity and burdens healthcare systems substantially. The FDA has approved several drugs to treat C. difficile infections, including Fidaxomicin (Dificid), Vowst, Rebyota, and Fecal microbiota transplantation (FMT). Recurrent infections affect approximately 15% to 35% of CDI patients, often representing a relapse of the same infection rather than a new strain causing reinfection. Second and subsequent recurrences are even more common following the first recurrence. In the United States alone, C. difficile infection is responsible for about half a million illnesses yearly.

• It is recognized as one of the most prevalent hospital-acquired infections, and one in 11 individuals over 65 succumbs to healthcare-associated C. difficile infection.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2021-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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