Published Date : 2022-09-30
Published Date : 2022-09-30
Updated On : 2023-07-02
Pages : 164
Thelansis’s “Cell Therapy Market Outlook, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Cell Therapy treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).
The cell therapy market is a rapidly evolving field in the medical industry focused on preventing and treating human diseases by using selected, multiplied, and pharmacologically treated cells administered outside the body (ex vivo). The therapy can encompass various pharmacological and nonpharmacological methods to modify the body's intrinsic cells for therapeutic purposes. Stem cells, particularly pluripotent stem cells (PSCs), adult stem cells (ASCs), and cancer stem cells (CSCs), are the primary focus of interest in cell therapy. Cell therapy combines stem and non–stem cell-based approaches, employing autologous or allogeneic cells that may undergo genetic engineering or other manipulations. The administration methods vary, including topical application, injectables, infusions, bioscaffolds, or scaffold-free systems. The applications of cell therapy span various therapeutic areas, including regenerative medicine, immunotherapy, and cancer therapy. Stem cells are crucial components in cell therapy and can be derived from embryos or adult cells. They possess the unique ability to differentiate into various cell types, making them highly valuable in therapeutic interventions. Aside from stem cells, non–stem cell-based therapies are also essential in cell therapy. These therapies involve somatic cells isolated from the patient's body, propagated, expanded, and administered to address curative, preventive, or diagnostic purposes. Examples of non–stem cell-based therapies include fibroblasts, chondrocytes, keratinocytes, hepatocytes, pancreatic islet cells, and immune cells such as T cells, dendritic cells (DCs), natural killer (NK) cells, and macrophages. With its wide range of applications and significant potential in various medical fields, the cell therapy market continues to show promising growth and advancements in developing innovative treatments for diverse diseases and conditions.
North America- the United States and Canada
Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)
Other countries- Japan & China
This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.
KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs
- Data Inputs with sourcing
- Market Event and Product Event
- Country-specific Forecast Model
- Market uptake and patient share uptake
- Attribute Analysis
- Analog Analysis
- Disease burden and pricing scenario
- Summary and Insights
Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.
The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.
Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.
This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.
| S. no | Asset | Company | Stage |
| 1 | Autologous cell therapy | BioCardia, Inc. | Phase 3 |
| 2 | Autologous EPCs transfected with human eNOS | Northern Therapeutics | Phase 3 |
| 3 | Posoleucel (ALVR105) | AlloVir | Phase 3 |
| 4 | AB-205 | Angiocrine Bioscience | Phase 3 |
| 5 | Photodynamic therapy (PDT) (ALA-PDT, Ameluz®-PDT) | Biofrontera Bioscience GmbH | Phase 3 |
| 6 | Axicabtagene Ciloleucel | Kite, A Gilead Company | Phase 3 |
| 7 | Ixazomib Citrate | Takeda | Phase 3 |
| 8 | Osimertinib | AstraZeneca | Phase 3 |
| 9 | Lenvatinib | Eisai Inc. | Phase 3 |
| 10 | Nivolumab | Bristol-Myers Squibb | Phase 3 |
Continued...
KOLs across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.
| COUNTRY | No. Of KOLs |
| USA | 17 |
| GERMANY | 4 |
| UK | 4 |
| SPAIN | 3 |
| FRANCE | 2 |
| ITALY | 3 |
| JAPAN | 3 |
| CHINA | 4 |
Data Inputs with sourcing, Market Event, Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.
1. Cell Therapy – Key Findings Summary |
| 1.1. Commercial Potential |
| 1.1.1. Market potential |
| 1.1.2. Therapeutic practices |
| 1.1.3. Market outlook |
| 1.2. Commercial findings |
| 1.2.1. Cell Therapy market scenario 2022 |
| 1.2.2. Cell Therapy market scenario 2027 |
| 1.2.3. Cell Therapy market scenario 2032 |
2. Cell Therapy Overview |
| 2.1. Introduction to Cell Therapy |
| 2.2. Pathogenesis |
| 2.3. Technology and platform |
| 2.4. Applications |
| 2.5. Risk Factors |
| 2.6. Therapeutic evolutions |
| 2.7. Clinical practice |
| 2.8. Cell Therapy adoption and clinical practice |
| 2.8.1. Treatment landscape for Cell Therapy in US |
| 2.8.2. Treatment landscape for Cell Therapy in EU-5 |
| 2.8.3. Treatment landscape for Cell Therapy in Japan |
| 2.8.4. Treatment landscape for Cell Therapy in China |
| 2.9. Treatment Goals for Cell Therapy |
| 2.10. Referral Patterns for Cell Therapy |
| 2.10.1. Referral Scenario in US |
| 2.10.2. Referral Scenario in EU-5 |
| 2.10.3. Referral Scenario in Japan |
| 2.10.4. Referral Scenario in China |
| 2.11. Cell Therapy Healthcare burden |
| 2.11.1. Cell Therapy Healthcare burden in US |
| 2.11.2. Cell Therapy Healthcare burden in EU-5 |
| 2.11.3. Cell Therapy Healthcare burden in Japan |
| 2.11.4. Cell Therapy Healthcare burden in China |
| 2.12. Current unmet Needs |
| 2.13. Market Opportunity for Cell Therapy |
| 2.14. Payer’s Expectations from Cell Therapy |
| 2.15. KOL Comments on Cell Therapy current and upcoming/expected clinical practices |
3. Market Outlook
|
| 3.1. US Cell Therapy Market Forecast 2022-2032 |
| 3.1.1. Market Progression (Futuristic) |
| 3.1.2. Market Trends and Expectations |
| 3.1.2.1. Worst Case Scenario |
| 3.1.2.2. Base Case Scenario |
| 3.1.2.3. Best Case Scenario |
| 3.1.3. Drivers and Barriers |
| 3.2. UK Cell Therapy Market Forecast 2022-2032 |
| 3.2.1. Market Progression (Futuristic) |
| 3.2.2. Market Trends and Expectations |
| 3.2.2.1. Worst Case Scenario |
| 3.2.2.2. Base Case Scenario |
| 3.2.2.3. Best Case Scenario |
| 3.2.3. Drivers and Barriers |
| 3.3. France Cell Therapy Market Forecast 2022-2032 |
| 3.3.1. Market Progression (Futuristic) |
| 3.3.2. Market Trends and Expectations |
| 3.3.2.1. Worst Case Scenario |
| 3.3.2.2. Base Case Scenario |
| 3.3.2.3. Best Case Scenario |
| 3.3.3. Drivers and Barriers |
| 3.4. Germany Cell Therapy Market Forecast 2022-2032 |
| 3.4.1. Market Progression (Futuristic) |
| 3.4.2. Market Trends and Expectations |
| 3.4.2.1. Worst Case Scenario |
| 3.4.2.2. Base Case Scenario |
| 3.4.2.3. Best Case Scenario |
| 3.4.3. Drivers and Barriers |
| 3.5. Italy Cell Therapy Market Forecast 2022-2032 |
| 3.5.1. Market Progression (Futuristic) |
| 3.5.2. Market Trends and Expectations |
| 3.5.2.1. Worst Case Scenario |
| 3.5.2.2. Base Case Scenario |
| 3.5.2.3. Best Case Scenario |
| 3.5.3. Drivers and Barriers |
| 3.6. Spain Cell Therapy Market Forecast 2022-2032 |
| 3.6.1. Market Progression (Futuristic) |
| 3.6.2. Market Trends and Expectations |
| 3.6.2.1. Worst Case Scenario |
| 3.6.2.2. Base Case Scenario |
| 3.6.2.3. Best Case Scenario |
| 3.6.3. Drivers and Barriers |
| 3.7. Japan Cell Therapy Market Forecast 2022-2032 |
| 3.7.1. Market Progression (Futuristic) |
| 3.7.2. Market Trends and Expectations |
| 3.7.2.1. Worst Case Scenario |
| 3.7.2.2. Base Case Scenario |
| 3.7.2.3. Best Case Scenario |
| 3.7.3. Drivers and Barriers |
| 3.8. China Cell Therapy Market Forecast 2022-2032 |
| 3.8.1. Market Progression (Futuristic) |
| 3.8.2. Market Trends and Expectations |
| 3.8.2.1. Worst Case Scenario |
| 3.8.2.2. Base Case Scenario |
| 3.8.2.3. Best Case Scenario |
| 3.8.3. Drivers and Barriers |
| 3.9. Key Expected Milestones (world-wide) Impacting the Market |
4. Competitive Landscape
|
| 4.1. Pipeline Therapies Overview |
| 4.2. Phase III/ II Profiles |
| 4.2.1. All Other Company (All Other Product) Profile |
| 4.2.1.1. Current Status |
| 4.2.1.2. Trial details, results (Targeted Disease Segments) |
| 4.2.1.3. Approval Timeline |
| 4.2.1.4. Likelihood of approval (KOL Comments) |
| 4.3. Phase I Profiles |
| 4.3.1. All Other Company (All Other Product) Profile |
| 4.3.1.1. Current Status |
| 4.3.1.2. Trial details, results (Targeted Disease Segments) |
| 4.3.1.3. Approval Timeline |
| 4.3.1.4. Likelihood of approval (KOL Comments) |
| 4.4. Preclinical/Phase I ready Therapies |
| 4.4.1. All Other Product (All Other Company) Profile |
| 4.4.1.1. Current Status (Targeted Disease Segments) |
| 4.4.1.2. Competitive Benchmarking |
| 4.4.1.3. Company Profile |
| 4.5. Attrition analysis |
| 4.5.1. Discontinued and Assets with No Development Reported |
| 4.5.2. Reasons and class-effect of discontinuations |
5. Regulatory/Approval Scenario for Cell Therapy
|
| 5.1. Regulatory/Approval Framework in US |
| 5.1.1. Policy Framework |
| 5.1.2. Payer Expectations |
| 5.2. Regulatory/Approval Framework in UK |
| 5.2.1. Policy Framework |
| 5.2.2. Payer Expectations |
| 5.3. Regulatory/Approval Framework in France |
| 5.3.1. Policy Framework |
| 5.3.2. Payer Expectations |
| 5.4. Regulatory/Approval Framework in Germany |
| 5.4.1. Policy Framework |
| 5.4.2. Payer Expectations |
| 5.5. Regulatory/Approval Framework in Italy |
| 5.5.1. Policy Framework |
| 5.5.2. Payer Expectations |
| 5.6. Regulatory/Approval Framework in Spain |
| 5.6.1. Policy Framework |
| 5.6.2. Payer Expectations |
| 5.7. Regulatory/Approval Framework in Japan |
| 5.7.1. Policy Framework |
| 5.7.2. Payer Expectations |
| 5.8. Regulatory/Approval Framework in China |
| 5.8.1. Policy Framework |
| 5.8.2. Payer Expectations |
6. Clinical Trial Assessment – Current and Future Paradigm of Cell Therapy
|
| 6.1. Distribution of Primary Endpoints across trials |
| 6.2. Distribution of Secondary Endpoints across trials |
| 6.3. Evolution and acceptance of surrogate endpoints |
| 6.4. Key Investigator initiated trials |
| 6.5. Attrition analysis |
| 6.5.1. Suspended/Discontinued Assets |
| 6.5.2. Failed Trials, Reasons and Business Impact |
| 6.5.3. Terminated Trials, Reasons and Business Impact |
| 6.5.4. Withdrawn Trials, Reasons and Business Impact |
| 6.6. Trial enrollment scenario and challenges |
| 6.7. Clinical Trial Guidance (across geographies) |
7. Thelansis Commentary
|
| 7.1. Key Unmet needs in Cell Therapy |
| 7.2. Possible Best-case Clinical Trial Strategies |
| 7.3. Possible Best Case Targeted Product Profile (TPP) |
| 7.4. Possible Best-case Market Positioning Strategies |
| 7.5. Possible Best-case Market Access Strategies |
| 7.6. Possible Best-case LCM Strategies |
| 7.7. Overall View on Cell Therapy Market in Dollar Value |
8. Report Methodology
|
| 8.1. Secondary research |
| 8.2. Primary research |
| 8.3. Data collation |
| 8.4. Insight Generation |
9. About Thelansis
|
| 9.1. Our Capabilities |
| 9.2. Our Services |
| 9.3. Our Contacts |
| 9.4. Disclaimer |
Head – Business Development and Partnering
Mr. Pankaj Negi has joined Thelansis as Practice Head; Business Development and Partnering, since Jan 2020. A dynamic professional with 12+ years of diverse experience across Pharmaceuticals/ Healthcare/ Life sciences with specialized in sales & marketing and Business Development.
Mr. Pankaj is holding a Master’s degree in “Pharma Management” from the Rajiv Gandhi University of Health Science, Bangalore, India and has expertise in Content Marketing, Content Management systems, Customer Relationship Management, online marketing, advertising, promotion, and Search Engine Optimization. Creating and implementing client-centered, successful campaigns, aimed at improving brand awareness and presence.
Vice President – Delivery, Scientific CI
Mukesh Kumar has joined us as Vice President – Delivery & Innovations, Scientific CI Practice, since August 2019. Prior to joining us, Dr. Mukesh holding a Postdoctoral Fellow with a demonstrated history of working in hard-core research for more than 15 years on both small molecule and biologics within the oncology and neurology segment.
Skilled in Recombinant DNA, Phage Display Technology, Antibodies, ImmunoOncology (K-RAS, Check-Point, Oncolytic), and Immunotherapeutic (RNA andProtein/huMab-based) products, Cancer-stem Cells, Chemoresistance, Real-TimePolymerase Chain Reaction (qPCR), and SDS-PAGE. Strong research professional with a Ph.D. focused on Recombinant Antibody-mediated tumor targeting. Dr.Mukesh has several citations on Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis, Membrane, Fusion Mediated Targeted Cytosolic DrugDelivery Through scFv Engineered Sendai Viral Envelopes, and Drug combination targeting hypoxia-induced chemoresistance and stemness in glioma cells.
Director – Practice Head, Competitive Intelligence, Market Access, and Pricing
Mr. Peeyush Potdar is working at Thelansis as Practice Head; Competitive Intelligence, Market Access, and Pricing Analytics, since Dec 2017. With 12+ years of rich experience in providing business consulting and research support across competitive intelligence, BD&L activities, KOL management, business research, and analytics services, he has been involved in the development of syndicated therapy area specialized reports in Orphan & ultra-orphan indications and conducting market intelligence assignments on different verticals such as Pharmaceuticals, Medical Devices and Health Insurance.
Mr. Peeyush is holding an MBA degree in “Pharma Management” from the National Institute of Pharmaceutical Education & Research (NIPER), Mohali, India and has expertise in scientific research as well as in commercialization and lifecycle management for innovative and mature assets. He has a good competency in building AI/ ML-based analytics platforms for tracking global conferences, social media analytics, and for conducting patient outcomes research.
Director – Global Relationship and Partnering US
Ms. Martina is working with us as Director – Global Relationship and Partnering US, since October 2019. Prior to joining us, Ms. Martina holding a Master’s Degree in Public Health from Boston University School of Public Health with more than 8 years of experience in B2B and B2C sales. Highly motivated and accomplished sales and marketing professional with a proven history of success in creating the road map and driving business development globally.
Part of US Leadership team and heading Business Development for Thelansis Knowledge Partner for both US and EU Region. Business Development opportunity identification, Engaging with the client and providing them with innovative business solutions.
Director – Global Relationship and Partnering EU
