Alcoholic Hepatitis (AH) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Alcoholic Hepatitis (AH) Market Outlook

Thelansis’s “Alcoholic Hepatitis (AH) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Alcoholic Hepatitis treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Alcoholic Hepatitis (AH) Overview

Alcohol stands as one of the most commonly consumed substances globally, socially embraced despite its harmful effects on the liver. Excessive alcohol intake results in various health issues, leading to substantial healthcare expenses related to alcohol-induced disorders. Among these, Alcoholic Hepatitis (AH) emerges as a critical and potentially life-threatening condition. This acute liver disease, often dubbed "acute alcoholic hepatitis," signifies the most severe form within the spectrum of alcoholic liver diseases. The clinical manifestation of AH varies widely, spanning from mild to severe cases. While clinical jaundice appears in 40%-60% of instances, nearly all AH patients exhibit hyperbilirubinemia, a hallmark of the disease. Additional symptoms include right upper quadrant pain, fever, increased heart rate, and an enlarged, tender liver. AH frequently intertwines with systemic inflammatory response syndrome (SIRS) and moderate fever, sometimes with underlying infections. Despite this, around 35% of heavy drinkers show signs of alcoholic steatohepatitis in liver biopsies without necessarily displaying the complete clinical syndrome. Diagnostic criteria for AH lack standardization or international consensus. However, a combination of mildly elevated liver enzymes, notably high serum bilirubin levels exceeding 80 μmol per liter, an increased INR, neutrophilia, and a history of heavy alcohol consumption strongly suggests AH. Unfortunately, there are currently no FDA-approved medications specifically for treating alcoholic hepatitis, leaving a gap in the pharmacotherapy options for alcoholic liver disease (ALD).

• The overall prevalence of Alcohol-Related Liver Disease (ARLD) in the general population is approximately 4.8%, with fluctuations ranging from 1.0% to 16.1%. Notably, prevalence tends to be higher among males compared to females.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

Visit our social media pages: