Adrenomyeloneuropathy (AMN) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032

Adrenomyeloneuropathy (AMN) Market Outlook

Thelansis’s “Adrenomyeloneuropathy (AMN) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Adrenomyeloneuropathy (AMN) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Adrenomyeloneuropathy (AMN) Overview

The adult-onset of X-linked Adrenoleukodystrophy, called as Adrenomyeloneuropathy (AMN), is characterized by ABCD1 gene mutation, which results in impaired peroxisome function with an accumulation of very long chain fatty acids (VLCFA) and demyelination. Adrenomyeloneuropathy (AMN) is mild, progresses slowly and is associated with an average life span in the ages of 21-35 years. The main symptoms include stiffness, weakness, paralysis of the lower limbs and loss of coordination. Women who are carriers of the disease occasionally experience the same symptoms along with ataxia, hypertonia, mild peripheral neuropathy and urinary problems. Individuals with X-ALD who reach their adulthood develop myelopathy and neuropathy, leading to AMN, in the age group of 30-40 years. The spinal cord and limber nerves are the only areas that initially exhibit symptoms. Before MR imaging was available, AMN was often misdiagnosed as multiple sclerosis or hereditary spastic paraparesis (HSP). In the majority of cases, this phenotype progresses gradually, resulting in severe motor disability in the lower limbs over one to two decades, but only mild or no noticeable deficits in the arms and hands.

• The diagnosed incidence of Adrenomyeloneuropathy (AMN) varies between 0.57 to 1.05 cases per 100,000 population in the USA.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2021-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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