Secondary Progressive Multiple Sclerosis (SPMS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Secondary Progressive Multiple Sclerosis (SPMS) Market Outlook

Thelansis’s “Secondary Progressive Multiple Sclerosis (SPMS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Secondary Progressive Multiple Sclerosis treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Secondary Progressive Multiple Sclerosis (SPMS) Overview

Secondary progressive multiple sclerosis (SPMS) represents the phase of the disease that follows the initial relapsing-remitting stage, characterized by a gradual decline in neurological function independent of relapses. While SPMS is typically viewed as a distinct subtype of multiple sclerosis, it shares some common pathological features and disease mechanisms with the relapsing-remitting form. The transition from relapsing-remitting MS to SPMS poses clinical challenges due to the variable nature of the disease, vague progression patterns, and the lack of established biomarkers and diagnostic tools. The primary treatment objective for SPMS is universally recognized as halting disease progression and preventing symptom exacerbation. Managing SPMS involves both pharmacological interventions, including drugs designed for relapsing cases and symptom-relief medications, as well as non-pharmacological approaches such as rehabilitation and physiotherapy to address symptoms like fatigue, cognitive impairment, and spasticity.

• In the United States, SPMS is estimated to affect approximately 19% to 25% of all individuals diagnosed with multiple sclerosis, with a prevalence ranging from 39 to 47 cases per 100,000 in the population.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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