Rhabdomyosarcoma (RMS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032

Rhabdomyosarcoma (RMS) Market Outlook

Thelansis’s “Rhabdomyosarcoma (RMS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Rhabdomyosarcoma (RMS) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Rhabdomyosarcoma (RMS) Overview

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. RMS can occur anywhere in the body, including the head and neck, genitourinary organs, extremities, and abdomen. Although still debated, evidence suggests that RMS arises from the mesenchymal cell lineage, which is typically fated to become skeletal muscle tissue. RMS is traditionally classified into two major histological subtypes, embryonal RMS (ERMS) and alveolar RMS (ARMS), of which 60–70% of cases are ERMS and 20–30% are ARMS. 80% of ARMS cases are defined by a chromosomal translocation between PAX3 or PAX7 and FOXO1 genes; these translocations result in fusion genes that largely drive oncogenic activity. The other 20% of ARMS cases are similar to ERMS in terms of clinical outcomes and the pattern of somatic mutations. Despite the clinical significance of RMS, the underlying etiologies remain the environmental and genetic factors individually contribute to this malignancy. 

• Approximately 50% of all pediatric soft-tissue sarcoma diagnoses are Rhabdomyosarcoma with an incidence of approximately 4.71 per million children and adolescents less than 20 years of age in the United States.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2021-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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