Primary IgA Nephropathy (IgAN) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Primary IgA Nephropathy (IgAN) Market Outlook

Thelansis’s “Primary IgA Nephropathy (IgAN) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Primary IgA Nephropathy treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Primary IgA Nephropathy (IgAN) Overview

IgA nephropathy (IgAN), the most prevalent form of primary glomerulonephritis globally, significantly contributes to chronic kidney disease and end-stage renal disease. It presents a diverse clinical and pathological course and is likely a group of diseases within the primary IgAN entity. It can also manifest secondary to various conditions like liver disease, coeliac disease, and several rheumatological disorders. Primary IgAN can present massive proteinuria (24-h urinary protein ≥3.5 g/d), with or without nephrotic syndrome (NS). Patients with ‘typical’ primary IgAN are categorized into three risk groups: low, intermediate, and high. Low-risk patients exhibit minor urinary abnormalities, normal GFR, and normotension. They require regular follow-up visits, which can be challenging to achieve in asymptomatic young individuals who need persuasion about the importance of regular review. Intermediate-risk patients have ‘significant’ proteinuria (mostly defined as >1 g per day but sometimes also as >0.5 g per day), which can be variably associated with hypertension and a slow reduction in GFR. A crucial subgroup of these patients is those with advanced CKD (eGFR <30–50ml/min/1.73m2) at the time of IgAN diagnosis. High-risk patients experience a rapid loss of GFR.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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