Pediatric Adrenocortical Cancer (ACC) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

Pediatric Adrenocortical Cancer (ACC) Market Outlook

Thelansis’s “Pediatric Adrenocortical Cancer (ACC) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Pediatric Adrenocortical Cancer (ACC) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Pediatric Adrenocortical Cancer (ACC) Overview

Pediatric Adrenocortical Cancer (ACC) is a rare neoplasm that affects the adrenal glands in children. The adrenal glands, located above the kidneys, produce hormones that regulate various physiological processes, including blood pressure, heart rate, and metabolism. Clinical presentation of pediatric ACC includes weight gain, hypertension, and changes in skin pigmentation. The genomic landscape of pediatric ACC is characterised by copy-neutral loss of heterozygosity on chromosomes 11 and 17, which is associated with germline TP53 pathogenic variants, insulin-like growth factor-2 overexpression, and somatic mutations in ATRX and CTNNB1. Li-Fraumeni Syndrome, an autosomal dominant familial cancer syndrome, is most commonly associated with pediatric ACC. Pediatric ACCs are more likely to be functional, often presenting with excess androgen production. The 5-year survival rate for pediatric ACC ranges from 30-70%, depending on disease presentation. The bimodal age distribution of pediatric ACC peaks under age five and after ten years, with 46% of diagnoses occurring in children under four years of age. The international TNM staging system classifies 44% of patients as stage I, 25% as stage II, 13% as stage III, and 17% as stage IV. The primary treatment for pediatric ACC is surgical resection, with adjuvant chemotherapy often employed depending on the results.

• Pediatric Adrenocortical Cancer (ACC) incidence ranges from 0.3 to 0.58 per million children under 15 years of age.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2022-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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