Oropharyngeal Squamous Cell Carcinoma (OPSCC) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Outlook and Forecast

Oropharyngeal Squamous Cell Carcinoma (OPSCC) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Published Date : 2023-04-25

Updated On : 2024-03-07

Pages : 154

Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Outlook

Thelansis’s “Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Oropharyngeal Squamous Cell Carcinoma treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Oropharyngeal Squamous Cell Carcinoma (OPSCC) Overview

Oropharyngeal cancer is a condition where cancerous cells develop in the tissues of the oropharynx, which constitutes the middle part of the pharynx. This area encompasses the tonsils, the back of the tongue, and the posterior throat walls. The pharynx serves as a passage for both air and food. Oropharyngeal cancers are commonly associated with HPV, and a positive HPV-16 polymerase chain reaction test of a biopsy or fine-needle aspiration is suggestive of oropharyngeal origin. Most oropharyngeal cancers are squamous cell carcinomas, thin, flat cells that line the interior of the oropharynx. Oropharyngeal cancer is relatively rare and typically afflicts individuals aged 50 to 80. The primary risk factors are smoking and excessive alcohol consumption. However, there has been a rise in cases among younger people infected with human papillomavirus (HPV). The signs and symptoms of oropharyngeal cancer can vary depending on the specific location, type, stage of cancer, and the individual genetic makeup of the tumor. These symptoms may include A lump in the neck or throat, Difficulty chewing or swallowing, along with pain, Sore throat, Unexplained ear pain, A persistent sore or ulcer lasting more than two weeks, Difficulty in mouth opening or tongue movement, A persistent white patch on the tongue or the lining of the mouth, Coughing up blood. Risk factors for oropharyngeal cancer can be attributed to environmental, behavioral, or genetic factors and include Tobacco use (cigarettes, pipes, cigars, chewing tobacco), Alcohol consumption, Exposure to human papillomavirus (HPV), including HPV type 16, A prior history of head and neck cancer.

  • The global incidence of oropharyngeal squamous cell carcinoma (OPSCC) is estimated to range from approximately 95,000 to 112,000 new cases each year. Over the last few decades, the incidence of OPSCC has been on the rise due to an increase in cases of human papillomavirus-positive (HPV+) OPSCC.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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Oropharyngeal Squamous Cell Carcinoma (OPSCC) Competitive Landscape

S. no Asset Company Stage
1 PRGN-2009 Precigen, Inc Phase 2
2 LSTA1 Lisata Therapeutics, Inc. Phase 2
3 CUE-101 Cue Biopharma Phase 3
4 Lenti-HPV-07 Theravectys S.A. Phase 2
5 ADXS11-001 (ADXS-HPV) Advaxis, Inc. Phase 2
6 ISA101b ISA Pharmaceuticals Phase 3
7 PDS0101 PDS Biotechnology Corp. Phase 2
8 APG-157 Aveta Biomics, Inc. Phase 2
9 NEXI-003 NexImmune Inc. Phase 2
10 SGX942 Soligenix Phase 3

Continued...

KOLs across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

COUNTRY No. Of KOLs
USA 17
GERMANY 4
UK 4
SPAIN 3
FRANCE 2
ITALY 3
JAPAN 3
CHINA 4

Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

Data Inputs with sourcing, Market Event, Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast

1.  Oropharyngeal Squamous Cell Carcinoma (OPSCC) – Key Findings Summary

         1.1.    Clinical findings
                     1.1.1. Disease overview
                     1.1.2. Therapeutic practices
                     1.1.3. Future outlook
         1.2.    Commercial findings
                     1.2.1. Oropharyngeal Squamous Cell Carcinoma (OPSCC) market scenario 2023
                     1.2.2. Oropharyngeal Squamous Cell Carcinoma (OPSCC) market scenario 2028
                     1.2.3. Oropharyngeal Squamous Cell Carcinoma (OPSCC) market scenario 2033

2. Oropharyngeal Squamous Cell Carcinoma (OPSCC) Overview

         2.1.    Disease Introduction
         2.2.    Pathophysiology
         2.3.    Signs and Symptoms
         2.4.    Risk Factors
         2.5.    Etiology
         2.6.    Classification
         2.7.    Pathogenesis
         2.8.    Diagnosis
         2.9.    Complications
         2.10. Treatment Algorithm
                     2.10.1.    Treatment in US (guidelines)
                     2.10.2.    Treatment in EU-5 (guidelines)
                     2.10.3.    Treatment in Japan (guidelines)
                     2.10.4.    Treatment in China (guidelines)
         2.11. Treatment Goals for Oropharyngeal Squamous Cell Carcinoma (OPSCC)
         2.12. Referral Patterns
                     2.12.1.    Referral Scenario in US
                     2.12.2.    Referral Scenario in EU-5
                     2.12.3.    Referral Scenario in Japan
                     2.12.4.    Referral Scenario in China
         2.13. Oropharyngeal Squamous Cell Carcinoma (OPSCC) Prognosis
         2.14. Healthcare burden
                     2.14.1.    Healthcare burden in US
                     2.14.2.    Healthcare burden in EU-5
                     2.14.3.    Healthcare burden in Japan
                     2.14.4.    Healthcare burden in China
         2.15.  Unmet Needs in Oropharyngeal Squamous Cell Carcinoma (OPSCC) management
         2.16.  Market Opportunity for Oropharyngeal Squamous Cell Carcinoma (OPSCC)
         2.17. KOL Comments on current and upcoming/expected treatment practices in Oropharyngeal Squamous Cell Carcinoma (OPSCC)

3.       Epidemiology

         3.1.    Epidemiology Overview
         3.2.    Epidemiology by Geography
                     3.2.1. Oropharyngeal Squamous Cell Carcinoma (OPSCC) Epidemiology in US (2023-2033)
                             3.2.1.1.              Incidence of Oropharyngeal Squamous Cell Carcinoma (OPSCC)
                             3.2.1.2.              Diagnosed cases
                             3.2.1.3.              Treatable Patient Pool
                             3.2.1.4.              Epidemiology Trends
                     3.2.2. Oropharyngeal Squamous Cell Carcinoma (OPSCC) Epidemiology in EU-5 (2023-2033)
                             3.2.2.1.              Incidence of Oropharyngeal Squamous Cell Carcinoma (OPSCC)
                             3.2.2.2.              Diagnosed cases
                             3.2.2.3.              Treatable Patient Pool
                             3.2.2.4.              Epidemiology Trends
                     3.2.3. Oropharyngeal Squamous Cell Carcinoma (OPSCC) Epidemiology in Japan (2023-2033)
                             3.2.3.1.              Incidence of Oropharyngeal Squamous Cell Carcinoma (OPSCC)
                             3.2.3.2.              Diagnosed cases
                             3.2.3.3.              Treatable Patient Pool
                             3.2.3.4.              Epidemiology Trends
                     3.2.4. Oropharyngeal Squamous Cell Carcinoma (OPSCC) Epidemiology in China (2023-2033)
                             3.2.4.1.              Incidence of Oropharyngeal Squamous Cell Carcinoma (OPSCC)
                             3.2.4.2.              Diagnosed cases
                             3.2.4.3.              Treatable Patient Pool
                             3.2.4.4.              Epidemiology Trends
         3.3.    Epidemiology Trends (World-wide)

4.       Market Outlook

         4.1.    US Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.1.1. Market Progression (Futuristic)
                     4.1.2. Market Trends and Expectations
                             4.1.2.1.              Worst case scenario
                             4.1.2.2.              Base Case Scenario
                             4.1.2.3.              Best Case Scenario
                     4.1.3. Drivers and Barriers
         4.2.    UK Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.2.1. Market Progression (Futuristic)
                     4.2.2. Market Trends and Expectations
                             4.2.2.1.              Worst case scenario
                             4.2.2.2.              Base Case Scenario
                             4.2.2.3.              Best Case Scenario
                     4.2.3. Drivers and Barriers
         4.3.    France Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.3.1. Market Progression (Futuristic)
                     4.3.2. Market Trends and Expectations
                             4.3.2.1.              Worst case scenario
                             4.3.2.2.              Base Case Scenario
                             4.3.2.3.              Best Case Scenario
                     4.3.3. Drivers and Barriers
         4.4.    Germany Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.4.1. Market Progression (Futuristic)
                     4.4.2. Market Trends and Expectations
                             4.4.2.1.              Worst case scenario
                             4.4.2.2.              Base Case Scenario
                             4.4.2.3.              Best Case Scenario
                     4.4.3. Drivers and Barriers
         4.5.    Italy Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.5.1. Market Progression (Futuristic)
                     4.5.2. Market Trends and Expectations
                             4.5.2.1.              Worst case scenario
                             4.5.2.2.              Base Case Scenario
                             4.5.2.3.              Best Case Scenario
                     4.5.3. Drivers and Barriers
         4.6.    Spain Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.6.1. Market Progression (Futuristic)
                     4.6.2. Market Trends and Expectations
                             4.6.2.1.              Worst case scenario
                             4.6.2.2.              Base Case Scenario
                             4.6.2.3.              Best Case Scenario
                     4.6.3. Drivers and Barriers
         4.7.    Japan Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.7.1. Market Progression (Futuristic)
                     4.7.2. Market Trends and Expectations
                             4.7.2.1.              Worst case scenario
                             4.7.2.2.              Base Case Scenario
                             4.7.2.3.              Best Case Scenario
                     4.7.3. Drivers and Barriers
         4.8.    China Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market Forecast 2023-2033
                     4.8.1. Market Progression (Futuristic)
                     4.8.2. Market Trends and Expectations
                             4.8.2.1.              Worst case scenario
                             4.8.2.2.              Base Case Scenario
                             4.8.2.3.              Best Case Scenario
                     4.8.3. Drivers and Barriers
         4.9.    Key Expected Milestones (world-wide) Impacting the Market

5.       Competitive Landscape

         5.1.    Pipeline Therapies Overview
                     5.1.1. Phase III Therapies
                                      5.1.1.1.                     Current Status
                                      5.1.1.2.                     Trial details, results
                                      5.1.1.3.                     Approval Timeline
                                      5.1.1.4.                     Likelihood of approval
                                      5.1.1.5.                     Expected Product Positioning
                             5.1.1.2.              All other Phase III Therapies …..
                             5.1.1.3.              Attribute Analysis of Phase III molecules
                     5.1.2.  Phase II and Phase I/II Therapies
                                      5.1.2.1.                     Current Status
                                      5.1.2.2.                     Trial details, results
                                      5.1.2.3.                     Approval Timelines
                     5.1.3. List of active Pre-clinical Therapies
                                      5.1.3.1.                     Status in Oropharyngeal Squamous Cell Carcinoma (OPSCC)
                                      5.1.3.2.                     Company positioning
                             5.1.3.2.              All other pre-clinical therapies
                     5.1.4. List of Inactive/discontinued assets
                             5.1.4.1.              Business impact of discontinuations on current pipeline
                     5.1.5. Potential winners from Oropharyngeal Squamous Cell Carcinoma (OPSCC) Pipeline
                             5.1.5.1.              Potential Blockbusters across the pipeline

6.       Regulatory/Approval Scenario

         6.1.    Regulatory/Approval Framework in US
                     6.1.1. Policy Framework
                     6.1.2. Payer Expectations
         6.2.    Regulatory/Approval Framework in UK
                     6.2.1. Policy Framework
                     6.2.2. Payer Expectations
         6.3.    Regulatory/Approval Framework in France
                     6.3.1. Policy Framework
                     6.3.2. Payer Expectations
         6.4.    Regulatory/Approval Framework in Germany
                     6.4.1. Policy Framework
                     6.4.2. Payer Expectations
         6.5.    Regulatory/Approval Framework in Italy
                     6.5.1. Policy Framework
                     6.5.2. Payer Expectations
         6.6.    Regulatory/Approval Framework in Spain
                     6.6.1. Policy Framework
                     6.6.2. Payer Expectations
         6.7.       Regulatory/Approval Framework in Japan
                     6.7.1. Policy Framework
                     6.7.2. Payer Expectations
         6.8.       Regulatory/Approval Framework in China
                     6.8.1. Policy Framework
                     6.8.2. Payer Expectations

7.       Clinical Trial Assessment – Current and Future Paradigm

         7.1.    Distribution of Primary Endpoints across trials
         7.2.    Distribution of Secondary Endpoints across trials
         7.3.    Evolution and acceptance of surrogate endpoints
         7.4.    Key Investigator initiated trials
         7.5.    Attrition analysis
                     7.5.1. Suspended/Discontinued Assets
                     7.5.2. Failed Trials, Reasons and Business Impact
                     7.5.3. Terminated Trials, Reasons and Business Impact
                     7.5.4. Withdrawn Trials, Reasons and Business Impact
         7.6.    Trial enrollment scenario and challenges
         7.7.    Clinical Trial Guidance (across geographies)

8.       Thelansis Commentary

         8.1.    Key Unmet needs in Oropharyngeal Squamous Cell Carcinoma (OPSCC)
         8.2.    Possible Best-case Clinical Trial Strategies
         8.3.    Possible Best Case Targeted Product Profile (TPP)
         8.4.    Possible Best-case Market positioning strategies
         8.5.    Possible Best-case Market Access Strategies
         8.6.    Possible Best-case LCM Strategies
         8.7.    Overall View on Oropharyngeal Squamous Cell Carcinoma (OPSCC) Market in Dollar Value

9.       Report Methodology

         9.1.    Secondary research
         9.2.    Primary research
         9.3.    Data collation
         9.4.    Insight Generation

10.   About Thelansis

         10.1.    Our Capabilities
         10.2.    Our Services
         10.3.    Our Contacts
         10.4.    Disclaimer