Multifocal Motor Neuropathy – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

Multifocal Motor Neuropathy Market Outlook

Thelansis’s “Multifocal Motor Neuropathy Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Multifocal Motor Neuropathy treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Multifocal Motor Neuropathy Overview

Multifocal motor neuropathy (MMN), also known as multifocal motor neuropathy with conduction block (MMNCB), is a rare and acquired form of motor neuropathy characterized by progressive asymmetric weakness without sensory involvement. Immune-mediated mechanisms are believed to be the underlying cause of the disease, as evidenced by the high prevalence of serum IgM anti-GM1 antibodies in affected individuals and the favourable response to treatment with intravenous immunoglobulin (IVIG). The concentration of GM1, a ganglioside found in the myelin of motor nerves, is higher in motor nerves than in sensory nerves, which may explain the selective motor involvement in MMN. The conduction block seen in electrophysiological studies in MMN is thought to be caused by anti-GM1 antibodies, which disrupt the function of sodium and potassium channels at the nodes of Ranvier, leading to decreased action potential propagation and reduced conduction velocity. Differential diagnoses of MMN include ALS, CIDP, and hereditary neuropathy with liability to pressure palsies (HNPP), radiculopathy, entrapment neuropathies, mononeuritis multiplex, hereditary motor neuropathies, porphyria, and lead intoxication. The primary pharmacological treatment option for MMNCB is intravenous immunoglobulin (IVIG), with a response rate of approximately 80%. In non-responders, treatment options are limited. The prognosis of MMN is generally good, with most patients being able to perform activities of daily living and remaining employed. The disease is rarely fatal due to the sparing of cranial and respiratory muscles. Complications of treatment, such as thromboembolic events, renal failure, anaphylactic reactions, and aseptic meningitis, may occur.

• In the USA and Japan, the prevalence of multifocal motor neuropathy ranges between 0.35 to 0.65 cases per 100,000 population. It affects more males than females, and onset usually occurs before 50 years of age.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2022-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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