Infantile Spasms (IS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Infantile Spasms (IS) Market Outlook

Thelansis’s “Infantile Spasms (IS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Infantile Spasms treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Infantile Spasms (IS) Overview

Infantile spasms, also known as West syndrome, represent a distinct and often devastating form of epilepsy affecting infants. It is characterized by unique seizure episodes called infantile spasms, which manifest as flexor, extensor, or mixed flexor-extensor spasms. These spasms are accompanied by a distinctive electroencephalography (EEG) pattern known as hypsarrhythmia and developmental delays or regressions. The syndrome can be categorized into two types based on etiology: symptomatic and cryptogenic. Symptomatic cases are associated with identifiable underlying causes or significant developmental delays preceding the onset of spasms. In contrast, cryptogenic cases lack such clear underlying causes and typically involve normal development before spasms onset. Causes of infantile spasms may stem from prenatal, perinatal, or postnatal factors, with approximately half of the cases attributed to prenatal factors, including central nervous system malformations, intrauterine insults, neurocutaneous syndromes such as tuberous sclerosis complex (TSC), metabolic disorders, and genetic syndromes like Down syndrome. Treatment options for infantile spasms include two medications, adrenocorticotropic hormone (ACTH) and vigabatrin, both supported by strong evidence of efficacy. Older drugs such as phenobarbital, carbamazepine, or phenytoin are seldom effective in managing this condition.

• Infantile spasms have an incidence of 1.6 to 4.5 per 10,000 live births, estimated to be about 2000 to 2500 new cases per year.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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