Idiopathic Hypersomnia (IH) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032

Idiopathic Hypersomnia (IH) Market Outlook

Thelansis’s “Idiopathic Hypersomnia (IH) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Idiopathic Hypersomnia treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Idiopathic Hypersomnia (IH) Overview

Idiopathic hypersomnia (IH) is a chronic neurological condition characterized by excessive daytime sleepiness, sometimes accompanied by extended sleep periods. Accurate estimates of IH prevalence are challenging due to the need for specialized testing and the need to rule out other disorders with similar symptoms. Clinical figures regarding IH's occurrence can vary significantly, with some studies indicating a 1:10 ratio compared to narcolepsy with cataplexy. It's noteworthy that a family history of excessive sleepiness or other hypersomnolence-related central disorders is evident in about 34-38% of IH patients, and 12.5% have at least one parent who consistently sleeps more than 9.5 hours per night. Distinguishing features of IH and narcolepsy type 1 (NT1) are quite clear: IH patients lack cataplexy, have efficient nighttime sleep with few awakenings, and experience long but unrefreshing naps. In contrast, NT1 patients have cataplexy, fragmented nocturnal sleep, and find short naps restorative. The diagnosis of IH is intricate, starting with the observation of excessive daytime sleep. A definitive diagnosis typically requires polysomnography and multiple sleep latency tests (MSLT), which should be conducted without sleep-affecting medication. Xywav, composed of calcium, magnesium, potassium, and sodium oxybates, is the sole FDA-approved treatment for idiopathic hypersomnia. Other treatments, such as wakefulness-promoting agents (modafinil and armodafinil) and psychostimulants (amphetamines and methylphenidate), are used off-label to address this condition.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2021-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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