Eisenmenger Complex – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

Eisenmenger Complex Market Outlook

Thelansis’s “Eisenmenger Complex Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Eisenmenger Complex treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Eisenmenger Complex Overview

Eisenmenger Complex is a clinical syndrome resulting from a congenital heart defect characterized by large anatomical shunts. Hemodynamic forces acting on these anatomic abnormalities initially cause a left-to-right shunt, leading to the development of severe pulmonary arterial hypertension (PAH) and increased vascular resistance. Eventually, due to elevated pulmonary vascular resistance, the direction of the shunt reverses, resulting in a right-to-left shunt and subsequent hypoxemia and cyanosis. Eisenmenger syndrome can arise from various heart defects that induce PAH, including atrial septal defects (ASD), ventricular septal defects (VSD), atrioventricular septal defects (AVSD), and patent ductus arteriosus (PDA), as well as more complex cardiac lesions. Unrepaired Tetralogy of Fallot (ToF) can also lead to the development of Eisenmenger syndrome. The most frequently observed defects associated with Eisenmenger syndrome are ASD, VSD, and PDA. The transformation of a left-to-right shunt into a right-to-left shunt involves three primary processes: vasoconstriction due to imbalances in pulmonary vascular tone, vascular remodeling resulting from the proliferation of pulmonary vascular smooth muscle, and thrombosis caused by increased blood flow resistance. The common clinical manifestations of Eisenmenger syndrome include angina (chest pain), arrhythmias (abnormal heartbeat), clubbing (abnormal enlargement and curvature of fingernails and toenails), hemoptysis (coughing up blood), and cyanosis. Individuals with Eisenmenger syndrome have reduced life expectancy, with high mortality rates occurring in the third and fourth decades of life. Ventricular failure, hemoptysis, complications during pregnancy, and strokes are common causes of death. Treatment for Eisenmenger syndrome aims to alleviate symptoms and prevent severe damage to the heart and lungs. Therapeutic approaches may include antibiotics, anticoagulants, diuretics, dual endothelin receptor antagonists, iron supplements, and supplemental oxygen.

• Approximately 1% to 6% of adults with congenital heart defects develop Eisenmenger syndrome.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2022-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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