Bronchiolitis Obliterans Syndrome (BOS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

Bronchiolitis Obliterans Syndrome (BOS) Market Outlook

Thelansis’s “Bronchiolitis Obliterans Syndrome (BOS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Bronchiolitis Obliterans Syndrome treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Bronchiolitis Obliterans Syndrome (BOS) Overview

Bronchiolitis obliterans syndrome, also known as obliterative bronchiolitis or constrictive bronchiolitis. When it occurs after a lung transplantation or hematopoietic stem cell transplantation (HSCT), it is specifically referred to as bronchiolitis obliterans syndrome. Bronchiolitis obliterans is a type of obstructive lung disease of the small airways, a form of chronic allograft rejection after lung transplantation. The most of lung transplant recipients who are long-term survivors develop bronchiolitis obliterans syndrome. It is estimated that more than 50% of recipients will develop some degree of BO within 5 years post-transplant, with an average time to diagnosis of 16 to 20 months after lung transplant, although it has been reported as early as 3 months after transplantation. Bronchiolitis obliterans characteristically presents with dyspnea and a cough that is persistent and progressive. Some may also have wheezing. Unlike asthma, these symptoms usually develop over weeks to months and are not episodic. The prognosis of bronchiolitis obliterans depends on the underlying pathology. While some patients achieve complete improvement; however, those with the constrictive disease generally demonstrate a more progressive course.

• Around 45% of recipients develop bronchiolitis obliterans syndrome by 5 years post-transplant. The average diagnosis time is 16 to 20 months after lung transplant or as early as 3 months after transplantation.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2022-2032

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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