Acquired Fibrinogen Deficiency (AFD) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Acquired Fibrinogen Deficiency (AFD) Market Outlook

Thelansis’s “Acquired Fibrinogen Deficiency (AFD) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Acquired Fibrinogen Deficiency treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Acquired Fibrinogen Deficiency (AFD) Overview

Acquired fibrinogen deficiency (AFD), often linked with significant blood loss, presents a recurrent challenge in critical care scenarios. Fibrinogen plays a pivotal role in clot formation, as a crucial protein for initiating and maintaining coagulation. Typically, normal fibrinogen levels range from 1.5 to 4.5 g/l, with increases observed during pregnancy. However, fibrinogen is notably the first clotting factor to decrease to critically low levels in cases of severe bleeding. Moreover, significant blood loss can exhaust the body's fibrinogen reserves. Conditions such as circulatory shock, certain carcinomas (e.g., prostate cancer), or sepsis can lead to excessive fibrinogen consumption, resulting in continuous clot formation and depletion of coagulation factors, ultimately leading to fibrinogen deficiency. Instances of low fibrinogen levels due to high fibrinogen usage are commonly associated with profuse bleeding or trauma during surgical procedures or accidents. Hypofibrinogenemia is recognized as a significant bleeding risk factor across various medical contexts, notably in trauma, obstetrics, and cardiovascular surgery. In France, Clottafact, a fibrinogen concentrate, has been approved for use in cases of massive bleeding associated with acquired fibrinogen deficiency.

Geography Covered:

North America- the United States and Canada

Europe- EU5 (Germany, France, Italy, Spain, and the United Kingdom)

Other countries- Japan & China

Study Period: 2023-2033

Current Clinical Practice and Treatment Algorithm

This section of the study covers country-specific current clinical practice, the standard of care, and significant limitations around addressing the unmet needs. Retrospective analysis and bench-marking of clinical study outcomes are presented in terms of Pre-treatment & post-treatment clinical and demographic patient characteristics. Essentially, this section will cover the evolution of the current competitive landscape and its impact on the future treatment paradigm.

KOL Insights:

KOLs across 8 MM markets from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs

Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard)

- Data Inputs with sourcing

- Market Event and Product Event

- Country-specific Forecast Model

- Market uptake and patient share uptake

- Attribute Analysis

- Analog Analysis

- Disease burden and pricing scenario

- Summary and Insights

NPV/ IRR Calculator-

Optimization of cash flow/ revenue flow concerning all fixed and variable investments throughout the product development process. The rate of return on an investment is a critical indicator to ensure the profitability and break-even of the project.

Competitive Landscape:

The competitive landscape includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review such as Orphan drug designation, Fast track, Priority Review, Breakthrough Therapy Designation, Rare Pediatric Disease Designation, and Accelerated Approval are tracked and supplemented with analyst commentary.

Clinical Trial Assessment-

Detailed clinical trial data analysis and critical product positioning include trial design, primary outcomes, secondary outcomes, dosing and schedules, inclusion and exclusion criteria, recruitment status and essentially covers the reported adverse events. Majorly the trial analysis helps determine the potential of the critical assets and their probable filing and launch date.

Unmet Medical Needs Overview-

This report presents the most important clinical unmet needs in the treatment, according to Thelansis research and analysis. Other essential unmet needs identified through our study include decreased cost burden on patients, improved administration convenience, and improved patient compliance.

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